RAS, cellular senescence and transformation
نویسندگان
چکیده
منابع مشابه
Oncogenic ras and p53 cooperate to induce cellular senescence.
Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway. To investigate whether p53 is sufficient to induce senescence, we introduced a conditional murine p53 allele (p53(val135)) into p53-null mouse embryonic fibroblasts and examined cell proliferation and...
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The kinesin family members (KIFs) KIF2A and KIF2C depolymerize microtubules, unlike the majority of other kinesins, which transport cargo along microtubules. KIF2A regulates the localization of lysosomes in the cytoplasm, which assists in activation of the mechanistic target of rapamycin complex 1 (mTORC1) on the lysosomal surface. We find that the closely related kinesin KIF2C also influences ...
متن کاملTranslation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence
Expression of oncogenic K-RAS in primary cells elicits oncogene-induced cellular senescence (OIS), a form of growth arrest that potently opposes tumourigenesis. This effect has been largely attributed to transcriptional mechanisms that depend on the p53 tumour suppressor protein. The PML tumour suppressor was initially identified as a component of the PML-RARα oncoprotein of acute promyelocytic...
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Oncogene-induced cellular senescence is well documented, but little is known about how infinite cell proliferation induced by loss of tumor suppressor genes is antagonized by cellular functions. Rb heterozygous mice generate Rb-deficient C cell adenomas that progress to adenocarcinomas following biallelic loss of N-ras. Here, we demonstrate that pRb inactivation induces aberrant expression of f...
متن کاملReport-The role of the PI3K/AKT and RAS/MEK/ERK/ETS pathways in cellular senescence
The INSPIRE scheme allows a select few students to gain real life research experience. This gives them a unique view point of the integration between current research and future treatment and the experience allows the students to fully consider if they wish to incorporate research into their medical or dentistry career. In July 2016 I was fortunate enough to be awarded the INSPIRE grant and spe...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2012
ISSN: 2154-1248,2154-1256
DOI: 10.4161/sgtp.19884